Every breath counts in the NICU, and precision is essential. Pressure-Targeted High Flow (PTHF) represents the next evolution in respiratory support, giving clinicians the ability to titrate high-flow nasal cannula therapy to a targeted pressure. Explore the clinical evidence behind PTHF.

CPAP and High Flow Therapy

The introduction of CPAP transformed the field of neonatology as the reliable distending pressure it produces prevents alveolar collapse, improves gas exchange, and reduces work of breathing. But CPAP therapy comes at a cost — high rates of nasal injury, disruption of skin-to-skin care, high nursing and RT workload.

Babies, parents and nurses love high-flow nasal cannula (HFNC) therapy as it is gentler, less intrusive and lower maintenance. But it’s also less effective than CPAP as it doesn’t generate a reliable PEEP — the degree of leak around the high flow prongs is impossible to assess yet is a prime driver of PEEP generation.

Measuring PEEP generation while on HFNC with a small, soft nasopharyngeal catheter provides an opportunity to combine the efficacy of CPAP with the ease of use of high flow. 

Is it time for the next transformation of NICU care, Pressure Targeted High Flow?

Clinical Literature

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High-flow nasal cannula: recommendations for daily practice in pediatrics

Review

Annals of Intensive Care

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Association Between High-Flow Nasal Cannula and End-Expiratory Esophageal Pressures in Premature Infants

Observational Study

Respiratory Care

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Physiological effects of high-flow nasal cannula therapy in preterm infants

Randomized Controlled Trial

BMJ Journals

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Positive distending pressure produced by heated, humidified high flow nasal cannula as compared to nasal continuous positive airway pressure in premature infants

Comparative Study

Sage Journals

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A comparison of nasal trauma in preterm infants extubated to either heated humidified high-flow nasal cannulae or nasal continuous positive airway pressure

Randomized Controlled Trial

European Journal of Pediatrics

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Comparison of the pharyngeal pressure provided by two heated, humidified high-flow nasal cannulae devices in premature infants

Randomized Controlled Trial

Journal of Paediatrics and Child Health

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Research in high flow therapy: Mechanisms of action

Review

Respiratory Medicine

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Patient comfort during treatment with heated humidified high flow nasal cannulae versus nasal continuous positive airway pressure

Randomized Controlled Trial

Archives of Disease in Childhood, Fetal and Neonatal Edition

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Respiratory mechanics during NCPAP and HHHFNC at equal distending pressures

Randomized Controlled Trial

Archives of Disease in Childhood, Fetal and Neonatal Edition

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Assessment of pain during application of nasal-continuous positive airway pressure and heated, humidified high-flow nasal cannulae in preterm infants

Observational Study

Journal of Perinatology

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High-Flow Nasal Cannulae in the Management of Apnea of Prematurity: A Comparison With Conventional Nasal Continuous Positive Airway Pressure

Clinical Trial

Pediatrics

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The Relationship Between High Flow Nasal Cannula Flow Rate and Effort of Breathing in Children

Clinical Trial

Journal of Pediatrics

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Mechanistic Understanding of High Flow Nasal Cannula Therapy and Pressure Support with an In Vitro Infant Model

Review

Annals of Biomedical Engineering

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Pharyngeal pressure with high-flow nasal cannulae in premature infants

Observational Study

Journal of Perinatology

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